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KMID : 0377519980230030139
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Chung-Ang Journal of Medicine
1998 Volume.23 No. 3 p.139 ~ p.144
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Effects of Nomsteroidal Antiinflammatory Drugs on Fracture Healing in Audult Rats
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Kang Soo-Yong
Lee Eun-Woo
Kang Ki-Ser
Kim Jin-Soo
Yoo Tae-Yeul
Kim Mi-Kyung
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Abstract
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This study was performed to evaluate the effects of nonsteroidal anti-inflammatory drugs(NSAIDs) on fracture healing in rats. The closed tibial fractures were induced via three-point bending technique. An NSAID, piroxicam(0.6mg/kg/day) was administered intramuscularly for 3 weeks. Control animals were received no medication. In each group, a minimum of five animals were killed at the following intervals: 3, 5, 7, 14, and 21 days postfracture. The fracture healing was determined by an immunohistochemical evaluation. The immunohistochemical evaluation was performed on serial longitudinal sections stained with proliferating cell nuclear antigen using percentage of stained cells. Significant difference was noticeable between two groups at 3 days. This data suggest that piroxicam has a possible inhibitory effect on initial fracture repair. So we should take care for prescribing NSAIDs for fracture patients.
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KEYWORD
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nosteroidal anti-inflammatory drug, fracture healing, proliferating cell nuclear antigen
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